In a medium saucepan, add the ketchup, brown sugar, apple cider vinegar, white vinegar, hickory liquid smoke, Worcestershire sauce, and Dijon mustard.

Whisk in the garlic powder, onion powder, smoked paprika, black pepper (both measures), and salt until fully combined. Place the saucepan over medium heat. Bring the mixture to a gentle boil, then reduce heat to low.

Let the sauce simmer uncovered for about 20 minutes, stirring occasionally. The sauce will thicken slightly as it cooks. Remove from heat and let cool. Transfer to a clean jar or bottle.